Insulin IQ製作的The Metabolic Classroom with Dr. Ben Bikman
Insulin IQ
Welcome to The Metabolic Classroom, a nutrition and lifestyle podcast focused on metabolism, which is how our bodies use energy, and the truth behind why we get sick and fat. Every week, Dr. Ben Bikman shares valuable insights that you can apply in your own life and share with friends and loved ones. The Metabolic Classroom is brought to you by InsulinIQ.com.
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分类: 健康
听听最后一集:
In today’s episode of The Metabolic Classroom, Dr. Ben Bikman delivers a lecture focusing on the drug rapamycin and its impact on longevity.
The primary discussion revolves around the role of the protein complex mTOR (mammalian target of rapamycin) in the body's aging process. While rapamycin is often touted as a drug that can inhibit mTOR and thereby promote longevity, Ben emphasizes that much of this belief is based on animal studies and lacks solid human evidence. The mTOR pathway is involved in cell growth and protein synthesis, particularly in muscle tissue, making its inhibition controversial when it comes to aging and muscle maintenance.
Dr. Bikman highlights that some research suggests reducing mTOR activity by lowering protein intake might promote longevity. However, he pointed out that for older populations, higher protein consumption is correlated with reduced mortality, particularly from animal protein sources. This is especially significant when considering muscle mass, which has been consistently linked to longer lifespan. Inhibiting mTOR might impair muscle growth and maintenance, making rapamycin problematic for those aiming to preserve muscle health as they age.
In addition to discussing the potential benefits of rapamycin, Ben underscores its negative side effects, including immune suppression, increased triglycerides (which elevate the risk of heart disease), and the inhibition of muscle protein synthesis. He also raises concerns about the drug’s ability to reduce testosterone levels and hinder reproductive health in both men and women. Given that reproduction is a key element of both evolutionary theory and many religious doctrines, Dr. Bikman questions the wisdom of using a drug that compromises reproductive function.
Dr. Bikman concludes by connecting the role of insulin to mTOR activation. He argues that insulin has a much stronger effect on mTOR than dietary protein does, and prolonged elevated insulin levels, common in modern diets, keep mTOR constantly active. This chronic activation of mTOR may hinder longevity more than protein intake or rapamycin inhibition.
Instead of relying on drugs like rapamycin, Ben suggests that reducing insulin levels through dietary interventions like fasting may be a more effective and natural way to manage mTOR activity and promote healthy aging.
My favorite meal-replacement shake: https://gethlth.com (discount: BEN10)
My favorite electrolytes (and more): https://redmond.life (discount: BEN15)
My favorite allulose source: https://rxsugar.com (discount: BEN20)
References:
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#Longevity #Rapamycin #AgingScience #mTOR #Healthspan #Autophagy #MuscleHealth #BenBikman #MetabolicHealth #HealthyAging #AntiAging #FastingBenefits #InsulinResistance #ImmuneHealth #ProteinSynthesis #HeartHealth #TestosteroneHealth #ReproductiveHealth #ScientificResearch #MetabolismMatters #BenBikman #DrBenBikman
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以前的剧集
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70 - Rapamycin and Longevity: What the Research Really Says with Dr. Ben Bikman Thu, 12 Sep 2024 - 0h
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69 - Leaky Gut Explained: Dr. Ben Bikman on Gut Health and Inflammation Thu, 05 Sep 2024 - 0h
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68 - How Hormones Control Obesity: The Fuel Partitioning Theory with Dr. Ben Bikman Wed, 04 Sep 2024 - 0h
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67 - Why A1C Isn't Enough: Insights from Dr. Ben Bikman with Dr. Ken Berry Mon, 26 Aug 2024 - 0h
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66 - The Impact of Estrogens on Glucose Metabolism and Insulin Resistance Fri, 16 Aug 2024 - 0h
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65 - Understanding Anabolic Resistance: Dr. Ben Bikman on Aging and Muscle Health Mon, 12 Aug 2024 - 0h
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64 - The Metabolic Health Benefits of Fermented Foods with Dr. Ben Bikman Thu, 08 Aug 2024 - 0h
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63 - The Randle Cycle: How Your Body Chooses Between Glucose and Fat Tue, 23 Jul 2024 - 0h
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62 - Leptin and Leptin Resistance Explained Thu, 18 Jul 2024 - 0h
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61 - Sarcopenic Obesity Fri, 28 Jun 2024 - 0h
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60 - Alcohol and Insulin Resistance Thu, 20 Jun 2024 - 0h
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59 - Energy Toxicity and Insulin Resistance Thu, 06 Jun 2024 - 0h
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58 - Sleep and Insulin Resistance Thu, 06 Jun 2024 - 0h
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57 - Exogenous Ketones with Dr. Ben Bikman Thu, 23 May 2024 - 0h
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56 - Heart Health: Fat Matters Mon, 20 May 2024 - 0h
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55 - Uric Acid with Dr. Ben Bikman Wed, 15 May 2024 - 0h
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54 - Saturated Fat with Dr. Ben Bikman Tue, 07 May 2024 - 0h
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53 - Salt and Cardiometabolic Health with Dr. Ben Bikman Thu, 02 May 2024 - 0h
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52 - Lipedema with Dr. Ben Bikman Wed, 24 Apr 2024 - 0h
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51 - The Metabolism of Male Infertility Thu, 18 Apr 2024 - 0h
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50 - The Metabolism of Female Infertility Thu, 11 Apr 2024 - 0h
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49 - Fatty Liver Disease with Dr. Ben Bikman Mon, 01 Apr 2024 - 0h
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48 - Strategies for Fat Burning with Dr. Ben Bikman Thu, 28 Mar 2024 - 0h
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47 - The Skinny on Fat: Sex and Fat Metabolism Thu, 21 Mar 2024 - 0h
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46 - Aging, and the Life of Fat with Dr. Ben Bikman Wed, 13 Mar 2024 - 0h
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45 - Why and Where We Store Fat Thu, 07 Mar 2024 - 0h
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44 - Drugs for Cardiovascular Health with Dr. Ben Bikman Thu, 29 Feb 2024 - 0h
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43 - Why Anti-Diabetic Drugs Usually Make Things Worse Thu, 22 Feb 2024 - 0h
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42 - What is GLP-1, What Does It Do, and Where Does It Come From? Wed, 14 Feb 2024 - 0h
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41 - Weight Loss Drugs Thu, 08 Feb 2024 - 0h
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40 - How to Measure and Fix Insulin Resistance Fri, 02 Feb 2024 - 0h
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39 - Why Does Insulin Resistance Matter? Thu, 25 Jan 2024 - 0h
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38 - Where Does Insulin Resistance Come From? Mon, 22 Jan 2024 - 0h
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37 - Insulin Resistance and Metabolic Syndrome Sun, 14 Jan 2024 - 0h
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36 - Leaky Gut and Nutrition Fri, 13 Aug 2021 - 0h
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35 - Low Carb Eating and Kidney Health Fri, 13 Aug 2021 - 0h
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34 - Can a Low-Carb Diet Cause Insulin Resistance? Fri, 16 Jul 2021 - 0h
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33 - Insulin Resistance & Women’s Reproductive Health Fri, 02 Jul 2021 - 0h
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32 - Caffeine, Insulin & Metabolism Fri, 02 Jul 2021 - 0h
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31 - The "Healthy" Whole Grain Question Fri, 18 Jun 2021 - 0h
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30 - Diving Deep Into Diabetes Fri, 28 May 2021 - 0h
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29 - Diving Into Diabetes Drugs Fri, 11 Jun 2021 - 0h
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28 - The Truth About Cholesterol Fri, 04 Jun 2021 - 0h
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27 - Metformin: The Magic & Misery Fri, 21 May 2021 - 0h
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26 - Decoding the Dawn Phenomenon Tue, 18 May 2021 - 0h
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25 - The Metabolic Side of Stress Fri, 14 May 2021 - 0h
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24 - Estrogen and Fat Storage Tue, 11 May 2021 - 0h
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23 - Leptin 101 Fri, 07 May 2021 - 0h
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22 - Fiber: Friend or Foe? Tue, 04 May 2021 - 0h
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21 - Insulin Resistance and Cognition Fri, 30 Apr 2021 - 0h